Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin ophthalmic (for use in the eyes) is used to treat bacterial infections of the eyes. Disease Entity Disease. Inflammation or infection of the conjunctiva is known as conjunctivitis and is characterized by dilatation of the conjunctival vessels, resulting in hyperemia and edema of the conjunctiva, typically with associated discharge. Bacterial infections are treated with antibiotics such as amoxicillin and ciprofloxacin. Aciclovir is an antiviral medicine used to treat viral infections. 5 Dermatologic (Skin) Adverse Effects Moderate/severe hypersensitivity (immune) reactions Clinical Presentation hives (raised, itchy rash) with or without fever Taking ofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. Avoid systemic quinolones, such as ofloxacin, in patients with a history of myasthenia gravis. Systemic quinolones may exacerbate the signs of myasthenia gravis and lead to life threatening weakness of the respiratory muscles. Consumer information about the medication OFLOXACIN - ORAL (Floxin), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug OFLOXACIN - ORAL. Compare prices and print coupons for Floxin (Ofloxacin) and other Skin Infection, Ear Infection, Eye Infection, Urinary Tract Infection, Bacterial Infection, Lower Respiratory Infection, and Pneumonia drugs at CVS, Walgreens, and other pharmacies. Prices start at $15.26 Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract (bladder and kidneys). OFLOXACIN is a quinolone antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.